The purpose of this study was to examine the effects of intermittent exercise on body composition, fat distribution and vasomotor symptoms in perimenopausal sedentary women. In this study participated that total 66 middle-aged with the phenomenon of hot flushes overweight sedentary women as volunteers. Body weight, Body composition (via skin folds caliper), waist hip ratio, waist circumference and body fat percentage were obtained from sedentary women. Besides subjects were asked menopausal bleeding patterns (including vasomotor symptoms) states with information form. The measurements were taken twice as before and after Pilates mat training program being applied a 6-week series of one hour exercise three days per week. The control group did not participate in any activity exercise program during the six-week period. There were significant differences between pretest and post test for weight, body mass index, waist circumference, waist hip ratio, fat percentage and body composition parameters in exercise group (p<0,05). Also, there were not significant differences between pretest and post test for same measurements in control group. According to subjects’ answers to was found that Pilates mat exercise had significantly effective on hot flushes from vasomotor symptoms at sedentary women. As a result, the findings support of Pilates mat exercises effects on weight loss and body composition parameters. Pilates mat exercises can have long-term benefits for women undergoing the menopausal transition.