This study provides updated findings that support the idea that exercise interventions have statistically significant effects on overall QOL in breast cancer survivors, as well as positive trends for cancer site-specific QOL domains (breast and arm symptoms). Based on the benefits of exercise interventions for breast cancer survivors, health care professionals could consider adopting exercise interventions as an integral component of the management of QOL in breast cancer survivors. Exercise intervention programs in the current review varied greatly. Further research is urgently needed to determine the essential attributers of exercise (mode, duration, frequency, and time per session) for optimal effects on the QOL of breast cancer survivors